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KMID : 1143420180110451518
Public Health Weekly Report
2018 Volume.11 No. 45 p.1518 ~ p.1522
Distribution of carbapenem-resistant Enterobacteriaceae (CRE) in Korea, 2017
Go Eun-Byeul

Ju Seong-Je
Yoo Jae-Il
Jeon Se-Mi
Abstract
The spread of carbapenem-resistant Enterobacteriaceae (CRE) has become a significant problem worldwide. In this study, we investigated the species, carbapenemase genotypes, and resistance rate of CRE in 2017. The susceptibility of CRE strains to carbapenem agents including imipenem, ertapenem, meropenem, and doripenem was tested. The carbapenemase gene was quantified by conventional PCR and analyzed by the sequence alignment method. The carbapenemase targets were IMP, OXA-48, VIM, NDM, KPC, and GES genes. According to the amino acid changes, specific genotypes were identified. Among 4,508 CRE strains, 2,953 were found to be carbapenemase-producing Enterobacteriaceae (CPE) strains. Most of the CRE strains were K. pneumoniae (55.7%) and E. coli (15.1%). The carbapenemase genotypes were classified into 44 types; the proportions of the KPC-2 and NDM-1 types were found to be 43.8% and 10.3%, respectively. The incidence of infections caused by CRE and carbapenemase -producing strains is increasing. Furthermore, the CPE genotype is continuously being expanded and newer CPE genotypes are being identified; this poses a dangerous threat to public health in Korea.
KEYWORD
Carbapenem-resistant Enterobacteriaceae, Carbapenemase-producing Enterobacteriaceae, Beta-lactamase KPC-2, Beta-lactamase NDM-1
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